Burkholderia pseudomallei and melioidosis

EM Meumann, D Limmathurotsakul… - Nature Reviews …, 2024 - nature.com
Burkholderia pseudomallei, the causative agent of melioidosis, is found in soil and water of
tropical and subtropical regions globally. Modelled estimates of the global burden predict …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

Recent advancement, immune responses, and mechanism of action of various vaccines against intracellular bacterial infections

A Ali, A Waris, MA Khan, M Asim, AU Khan, S Khan… - Life Sciences, 2023 - Elsevier
Emerging and re-emerging bacterial infections are a serious threat to human and animal
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …

Extracellular vesicles as antigen carriers for novel vaccination avenues

M Mehanny, CM Lehr, G Fuhrmann - Advanced drug delivery reviews, 2021 - Elsevier
Antigen delivery has always been a challenge in scientific practice of vaccine formulation.
Yet, mammalian extracellular vesicles (EVs) or bacterial membrane vesicles (MVs) provide …

[HTML][HTML] Bacteria and bacterial derivatives as delivery carriers for immunotherapy

SR Kang, DH Nguyen, SW Yoo, JJ Min - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

GMMA-based vaccines: the known and the unknown

F Mancini, F Micoli, F Necchi, M Pizza… - Frontiers in …, 2021 - frontiersin.org
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived
from Gram-negative bacteria engineered to provide an over-vesiculating phenotype, which …

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

BJ Currie - Current Opinion in Infectious Diseases, 2022 - journals.lww.com
Melioidosis and Burkholderia pseudomallei: progress in epide... : Current Opinion in Infectious
Diseases Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis …

Bacterial-derived outer membrane vesicles are potent adjuvants that drive humoral and cellular immune responses

JT Prior, C Davitt, J Kurtz, P Gellings, JB McLachlan… - Pharmaceutics, 2021 - mdpi.com
Discovery and development of novel adjuvants that can improve existing or next generation
vaccine platforms have received considerable interest in recent years. In particular …

Exosomes: biological pharmaceutical nanovectors for theranostics

SC Thomas, JW Kim, GM Pauletti… - … in bioengineering and …, 2022 - frontiersin.org
Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular
crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby …

Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses

S Bhar, G Zhao, JD Bartel, H Sterchele… - Frontiers in …, 2022 - frontiersin.org
Human norovirus is the primary cause of non-bacterial gastroenteritis globally and is the
second leading cause of diarrheal deaths in children in developing countries. However …