Summary Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in
mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis …

The maintenance of protein homeostasis (proteostasis) is a fundamental aspect of cell
physiology that is essential for the survival of organisms under a variety of environmental …

Dapagliflozin (DAPA) confers significant protection against heart and kidney diseases.
However, whether DAPA can alleviate type 4 cardiorenal syndrome (CRS-4)-related …

During tumorigenesis, the shift from oxidative phosphorylation to glycolysis in ATP
production accounts for the dramatic change in the cellular metabolism and represents one …

Intestinal handling of dietary proteins usually prevents local inflammatory and immune
responses and promotes oral tolerance. However, in~ 1% of the world population, gluten …

The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes
fibrogenic remodeling associated with loss of pulmonary arterial (PA) and cardiac …

We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host's
inflammatory response during bacterial infections. In this study, we investigated whether the …

Abstract Heat‐shock factor 1 (HSF 1) is the master transcription factor that regulates the
response to proteotoxic stress by controlling the transcription of many stress‐responsive …

Prostate cancer (PCa) is a leading cause of death among men. The dysregulation of
metabolism and autophagy contributes to the progression of PCa. The transcription factor …

Serotonin (5-HT) is a key player in many physiological processes in both the adult organism
and developing embryo. One of the mechanisms for 5-HT-mediated effects is covalent …