Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Stimulation of muscarinic M3 and M2 receptors on gastrointestinal smooth muscle elicits
contraction via activation of G proteins that are coupled to a diverse set of downstream …

Background and aims Mechanisms of the progression from Barrett's oesophagus to
oesophageal adenocarcinoma (OA) are not fully understood. Bile acids may have an …

Gastroesophageal reflux disease complicated by Barrett esophagus (BE) is a major risk
factor for esophageal adenocarcinoma (EA). The mechanisms whereby acid reflux may …

Bile reflux is a risk factor in the development of intestinal metaplasia in the stomach and is
believed to function as an initiator of gastric carcinogenesis. However, whether the G protein …

Rationale: Mechanisms underlying vasomotor abnormalities and increased peripheral
resistance exacerbating heart failure (HF) are poorly understood. Objective: To explore the …

Esophageal adenocarcinoma carries a poor prognosis associated with a 5-year survival rate
of 12.5–20%. Therefore, a new therapeutic modality is needed for this lethal tumor. Carnosol …

Contraction of esophageal (Eso) and lower esophageal sphincter (LES) circular muscle
depends on distinct signal-transduction pathways. ACh-induced contraction of Eso muscle is …

We have shown that the NADPH oxidase NOX5-S may play an important role in the
progression from Barrett's esophagus to esophageal adenocarcinoma (EA) by increasing …

Clinical studies have shown that probiotics influence gastrointestinal motility. However, the
molecular mechanisms by which probiotic Lactobacillus modulates intestinal motility in …