This report reviews the literature on the genotoxicity of mainstream tobacco smoke and
cigarette smoke condensate (CSC) published since 1985. CSC is genotoxic in nearly all …

The objective of this state of the art paper is to review the mechanisms of induction, the fate,
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …

Folic acid plays a critical role in the prevention of chromosome breakage and
hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) …

Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a
standard method for monitoring chromosome damage in human populations. The first …

Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has
been recently supported by the results of epidemiological studies that associated CA …

Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …

Cytogenetic biomarkers are by far the most frequently used endpoints in human population
studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early …

The pioneering papers published more than one century ago by Theodor Boveri opened the
way to extensive research on the mechanism linking chromosomal abnormalities to the …

Background DNA hypomethylation has been suggested to cause genomic instability and
increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is …

The field of molecular epidemiology is very promising, as sophisticated techniques are
being developed to address etiology, genetic susceptibility and mechanisms for induction of …