Engineered protein hydrogels as biomimetic cellular scaffolds

Y Liu, AE Gilchrist, SC Heilshorn - Advanced materials, 2024 - Wiley Online Library
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …

Programmability and biomedical utility of intrinsically-disordered protein polymers

MC Giraldo-Castano, KA Littlejohn… - Advanced Drug Delivery …, 2024 - Elsevier
Intrinsically disordered proteins (IDPs) exhibit molecular-level conformational dynamics that
are functionally harnessed across a wide range of fascinating biological phenomena. The …

Spatially heterogeneous tubular scaffolds for in situ heart valve tissue engineering using melt electrowriting

NT Saidy, A Fernández‐Colino… - Advanced Functional …, 2022 - Wiley Online Library
Heart valve tissue engineering (HVTE) aims to provide living autologous heart valve
implants endowed with regenerative capabilities and life‐long durability. However …

Building osteogenic microenvironments with a double-network composite hydrogel for bone repair

J Li, J Ma, Q Feng, E Xie, Q Meng, W Shu, J Wu, L Bian… - Research, 2023 - spj.science.org
The critical factor determining the in vivo effect of bone repair materials is the
microenvironment, which greatly depends on their abilities to promote vascularization and …

Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects

E Daskalakis, MH Hassan, AM Omar, AA Acar, A Fallah… - Polymers, 2023 - mdpi.com
This research investigates the accelerated hydrolytic degradation process of both
anatomically designed bone scaffolds with a pore size gradient and a rectangular shape …

Natural polymer-based scaffolds for soft tissue repair

M Chen, R Jiang, N Deng, X Zhao, X Li… - … in Bioengineering and …, 2022 - frontiersin.org
Soft tissues such as skin, muscle, and tendon are easily damaged due to injury from
physical activity and pathological lesions. For soft tissue repair and regeneration …

Protease‐Sensitive, VEGF‐Mimetic Peptide, and IKVAV Laminin‐Derived Peptide Sequences within Elastin‐Like Recombinamer Scaffolds Provide Spatiotemporally …

F González‐Pérez, M Alonso… - Advanced …, 2022 - Wiley Online Library
Spatiotemporal control of vascularization and innervation is a desired hallmark in advanced
tissue regeneration. For this purpose, we design a 3D model scaffold, based on elastin‐like …

[HTML][HTML] Engineering tunable dual peptide hybrid coatings promote osseointegration of implants

Z Shou, Z Bai, H Zhou, Y Shen, X Huang, H Meng… - Materials Today Bio, 2024 - Elsevier
Utilizing complementary bioactive peptides is a promising surface engineering strategy for
bone regeneration on osteogenesis. In this study, we designed block peptides,(Lysine) 6 …

The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair

Y Guo, S Liu, D Jing, N Liu, X Luo - Journal of Nanobiotechnology, 2023 - Springer
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural
elastin. These peptides have a low critical solution temperature phase behavior and can be …

Biohybrid elastin-like venous valve with potential for in situ tissue engineering

F González-Pérez, S Acosta, S Rütten… - … in bioengineering and …, 2022 - frontiersin.org
Chronic venous insufficiency (CVI) is a leading vascular disease whose clinical
manifestations include varicose veins, edemas, venous ulcers, and venous hypertension …