Cancer is a disease caused by the uncontrolled, abnormal growth of cells in different
anatomic sites. In 2018, it was predicted that the worldwide cancer burden would rise to 18.1 …

As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

Breast cancer (BC) is one of the main types of cancer that endangers women's lives. The
characteristics of triple-negative breast cancer (TNBC) include a high rate of recurrence and …

Medicinal plants serve as a valuable source of secondary metabolites since time
immemorial. Computational Research in 21st century is giving more attention to medicinal …

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase portraying a
quintessential role in cellular proliferation and survival. Aberrations in the mTOR signaling …

The present work analyzed the antibacterial, cytotoxic, and antidiabetic activities of
endophytic Diaporthe eres (SPEF004). The profiling of bioactive molecules was determined …

Ailanthone (AIT) is a quassinoid natural product isolated from the worldwide‐distributed
plant Ailanthus altissima. The drug displays multiple pharmacological properties, in …

Methods: A total of 35 adult female BALB/C mice were used in this study. Breast cancer was
induced by subcutaneous injection of 4T1 cells in the right lower flank. The mice received …

Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side
chains. Its upregulated expression is implicated in tumor growth, metastasis and …

Endophytes are prolific producers of privileged secondary metabolites with diverse
therapeutic potential, although their anticancer and antimicrobial potential still have a room …