Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration
MK Sun, DL Alkon - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …
impaired/lost neuronal structures and functions due to a long progression of …
Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer's …
Background Despite the high sensitivity of cerebrospinal fluid (CSF) amyloid beta (Aβ) 42 to
detect amyloid pathology, the Aβ42/Aβ40 ratio (amyR) better estimates amyloid load, with …
detect amyloid pathology, the Aβ42/Aβ40 ratio (amyR) better estimates amyloid load, with …
Rethinking of Alzheimer's disease: Lysosomal overloading and dietary therapy
S Yuan, SC Jiang, ZW Zhang, YF Fu… - Frontiers in Aging …, 2023 - frontiersin.org
The amyloid precursor protein (APP) is infamous for its putatively critical role in the
pathogenesis of Alzheimer's disease (AD)(Kim et al., 2022; Lee et al., 2022; Öhman et al …
pathogenesis of Alzheimer's disease (AD)(Kim et al., 2022; Lee et al., 2022; Öhman et al …
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice
Z Hu, J Yang, S Zhang, M Li, C Zuo… - Neural Regeneration …, 2025 - journals.lww.com
The E3 ubiquitin ligase, carboxyl terminus of heat shock protein 70 (Hsp70) interacting
protein (CHIP), also functions as a co-chaperone and plays a crucial role in the protein …
protein (CHIP), also functions as a co-chaperone and plays a crucial role in the protein …
Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer disease mouse model via enhancing neurotrophic and synaptic signaling
HB Taha, A Birnbaum, I Matthews, K Aceituno, J Leon… - bioRxiv, 2024 - biorxiv.org
INTRODUCTION: Skeletal muscle regulates central nervous system (CNS) function and
health, activating the muscle-to-brain axis through the secretion of skeletal muscle …
health, activating the muscle-to-brain axis through the secretion of skeletal muscle …
Protection against APOE4-associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice
CJ McGill, A Christensen, W Qian, MA Thorwald… - bioRxiv, 2024 - biorxiv.org
The apolipoprotein ϵ4 allele (APOE4) is associated with decreased longevity and increased
vulnerability to age-related declines and disorders across multiple systems. Interventions …
vulnerability to age-related declines and disorders across multiple systems. Interventions …
Iron associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice
The role of reactive iron in Alzheimer's Disease (AD) remains unresolved. Little is known of
how AD may alter iron transport, glutathione-mediated oxidative repair, and their …
how AD may alter iron transport, glutathione-mediated oxidative repair, and their …