Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on
prostate cancer development and progression. Here, we report on mitochondrial respiration …

Purpose: The major obstacle in the management of advanced prostate cancer is the
occurrence of resistance to endocrine therapy. Although the androgen receptor (AR) has …

Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its
normal counterpart. We report the reconstitution of the original human prostate cancer …

Prostate cancer (PCa) is one of the most common causes of male cancer-related death in
Western nations. The cellular response to androgens is mediated via the androgen receptor …

Understanding normal and cancer stem cells may provide insight into the origin of and new
therapeutics for prostate cancer. Normal and cancer stem cells in prostate have recently …

Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we
applied high-throughput screening to systematically explore most currently marketed drugs …

Current existing therapies for prostate cancer eradicate the majority of cells within a tumor.
However, most patients with advanced cancer still progress to androgen-independent …

The p53 gene is mutated in many human tumors. Cells of such tumors often contain
abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression …

Background Prostate cancer is a broad-spectrum disease, spanning from indolent to a
highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to …

The ability of human adipose tissue–derived mesenchymal stem cells (AT-MSCs),
engineered to express the suicide gene cytosine deaminase:: uracil …