The ability of zinc to retard oxidative processes has been recognized for many years. In
general, the mechanism of antioxidation can be divided into acute and chronic effects …

▪ Abstract Metallothioneins (MT) are low-molecular-weight, cysteine-rich, metal-binding
proteins. MT genes are readily induced by various physiologic and toxicologic stimuli …

It is generally accepted that the principal roles of metallothionein lie in the detoxification of
heavy metals and regulation of the metabolism of essential trace metals. However, there is …

MTs are small cysteine-rich metal-binding proteins found in many species and, although
there are differences between them, it is of note that they have a great deal of sequence and …

Bismuth compounds are used for the treatment of gastrointestinal disorders and may also be
useful for the treatment of other diseases. Bi (III) exhibits a highly variable coordination …

The antioxidant function of metallothionein (MT) was first suggested in the early 1980s.
Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including …

Cardiomyopathy induced by doxorubicin (DOX) has long been a major impediment of
clinical applications of this effective anticancer agent. Previous studies have shown that …

Anthracyclines play a major role in the treatment of solid malignancies, but their clinical use
is limited by acute or chronic cardiac toxicity. This is not due to the same molecular action …

Bismuth complexes are widely used as anti-ulcer drugs and can significantly reduce the side
effects of platinum anti-cancer drugs. Bismuth is known to induce the synthesis of …

Bismuth compounds have been widely used in medicine for more than 200 years, and new
bismuth‐containing drugs are now being developed. However the biological chemistry of …