Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …

Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

In this experimental randomized placebo-controlled 4-way crossover trial, we explored the
analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with …

Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …

Background: Peripheral neuropathy can significantly impact the quality of life for those who
are affected, as therapies from the current treatment algorithm often fail to deliver adequate …

Background Endocannabinoid dysfunction in animal models of autism spectrum disorder
(ASD) and accumulating, albeit anecdotal, evidence for efficacy in humans motivated this …

Background: Numerous physical, psychological, and emotional benefits have been
attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia …

Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented
phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different …

Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …