Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

Obesity and type 2 diabetes mellitus (T2DM) are metabolic disorders characterized by
metabolic inflexibility with multiple pathological organ manifestations, including non …

Background The Mexican population and others with Amerindian heritage exhibit a
substantial predisposition to dyslipidemias and coronary heart disease. Yet, these …

Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver
diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have …

Liver X receptors (LXRs) are members of the nuclear receptor family and are present in two
isoforms, α and β, encoded by two separate genes. Originally described in the liver, LXRs …

Clinical obesity is a complex metabolic disorder affecting one in three adults. Recent reports
suggest that pregnane X receptor (PXR), a xenobiotic nuclear receptor important for defense …

Since it is associated to the obesity epidemic, non alcoholic fatty liver disease (NAFLD) has
become a major public health issue. NAFLD ranges from benign hepatic steatosis, ie …

The link between cholesterol homeostasis and male fertility has been clearly suggested in
patients who suffer from hyperlipidemia and metabolic syndrome. This has been confirmed …

Liver X receptors (LXRs) are nuclear receptors that play a central role in cholesterol
metabolism. When activated, LXRs induce a series of genes that are involved in cholesterol …

Liver X receptors (LXRs) α and β are nuclear receptors whose transcriptional activity is
regulated by oxysterols, the oxidized forms of cholesterol. Described in the late 1990s as …