Myocardial infarction (MI) and heart failure (HF) are the leading causes of death in the
United States and in most other industrialized nations. MI leads to a massive loss of …

Collagen turnover is a slow process on a biologic timescale with at 1 2 of 20–27 days that is
mediated primarily by the matrix metalloproteinases (MMPs). Low collagen metabolism is …

Objectives: The aim of this study was to examine the effects of sarcoplasmic reticulum Ca2+
ATPase (SERCA2a) gene transfer in a swine heart failure (HF) model. Background …

Background—The noninvasive, tissue-specific delivery of therapeutic agents to the heart
would be a valuable clinical tool. This study addressed the hypothesis that albumin-coated …

Background—Noninvasive, tissue-specific delivery of therapeutic agents would be a
valuable clinical tool. We have previously shown that ultrasound-targeted microbubble …

Increased coronary blood vessel development could potentially benefit patients with
ischemic heart disease. In a model of stress–induced myocardial ischemia, intracoronary …

Nucleic acid drugs have great potential to treat many devastating aliments, but their
application has been hindered by the lack of efficacious and nontoxic delivery vehicles …

We used a catheter-based technique to achieve generalized cardiac gene transfer in vivo
and to alter cardiac function by overexpressing phospholamban (PL) which regulates the …

Objectives: This study was undertaken to optimize echocardiographic parameters for
successful gene delivery to the heart and to extend the method from adenoviral to plasmid …

Abnormal excitation–contraction coupling is a key pathophysiologic component of heart
failure (HF), and at a molecular level reduced expression of the sarcoplasmic reticulum (SR) …