Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic
proportions. While multiple theories regarding the roles of sleep exist (inactivity, energy …

Ample sleep is an important basis for maintaining health, however with the pace of life
accelerating in modern society, more people are using sacrificial sleep to cope with these …

GSK3 is a promising target for the treatment of Alzheimer's disease. Here, we describe the
design and synthesize of a series of GSK3 degraders based on a click chemistry platform. A …

Sleep deprivation (SD) has deleterious effects on cognitive functions including learning and
memory. However, some studies have shown that SD can improve cognitive functions …

The modified multi-platform method (MMPM) is used to induce animal models of paradoxical
sleep deprivation and impairs memory in rodents. However, variations in MMPM protocols …

Evidence has shown the beneficial effects of exercise on learning and memory. However,
many studies have reported controversial results, indicating that exercise can impair …

We examine the novel hypothesis that physical exercise and sleep have synergistic effects
on memory. Exercise can trigger mechanisms that can create an optimal brain state during …

Caffeine is a psychostimulant substance that is mostly used to prevent fatigue, increase
alertness, and ameliorate sleep loss situations. In this study, we aimed to investigate the …

Numerous studies have shown the deleterious effects of sleep deprivation (SD) on memory.
However, SD in various durations may induce different effects. Studies have reported that …

Sleep disturbances and Alzheimer's disease have deleterious effects on various
physiological and cognitive functions including synaptic plasticity, oxidative stress …