Peripheral nerve injuries (PNIs) are the most common injury types to affect the nervous
system. Restoration of nerve function after PNI is a challenging medical issue. Extended …

Fast advancements of microfabrication processes in past two decades have reached to a
fairly matured stage that we can manufacture a wide range of microfluidic devices. At …

Controlled release polymer vesicles are prepared using hydrolysable diblock copolymers of
polyethyleneglycol–poly-l-lactic acid (PEG–PLA) or polyethyleneglycol–polycaprolactone …

Due to their small particle size and large and modifiable surface, nanoparticles have unique
advantages compared with other drug carriers. As a research focus in recent years …

Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to
1000 nm (50–300 nm generally). They cannot freely diffuse through the blood-brain barrier …

The delivery of drugs to brain tumors is limited by the presence of the blood–brain barrier
(BBB) separating the blood from the cerebral parenchyma. An understanding of the specific …

Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) enables cancer
cells to develop resistance to multiple anticancer drugs. Functional inhibitors of P-gp have …

Drug resistance is a major obstacle to the success of cancer chemotherapy. Overexpression
of the drug-efflux transporter P-glycoprotein (P-gp) is a key factor contributing to tumor drug …

Targeted drug delivery using nanocarriers is achieved by functionalizing the carrier surface
with a tissue-recognition ligand. Current surface modification methods require tedious and …

The oral absorption of drugs that have poor bioavailability can be enhanced by
encapsulation in polymeric nanoparticles. Transcellular transport of nanoparticle …