Co-delivery nanoparticles with characteristics of intracellular precision release drug have
been generally accepted as an effective therapeutic strategy for eye diseases. In this study …

Abstract Heat Shock Protein 90 (Hsp90) has been extensively explored as a potential drug
target for cancer therapies. 17-N-allylamino-17-demethoxygeldanamycin (17AAG) was the …

Multiple-drug combination therapy is becoming more common in the treatment of advanced
cancers because this approach can decrease side effects and delay or prevent drug …

Objective: The aim of this study is to design, fabricate and determine the cytotoxic effects of
dual loaded paclitaxel and 17-AAG in stealth polymeric nanoparticles. The nanoparticles …

When exposed to cancer cells, cytotoxic drugs such as doxorubicin (DOX) can lead to the
induction of heat shock protein 90 (Hsp90), a molecular chaperone associated with a …

Heat shock protein (HSP90) is a molecular chaperone involved in numerous physiological
processes. The primary role of this is to assist in the process of protein folding and to restore …

Suboptimal chemotherapy of anticancer drugs may be attributed to a variety of cellular
mechanisms, which synergize to dodge the drug responses. Nearly 2 decades of heat-shock …

Background: Combination chemotherapy capable of overcoming cancer drug resistance can
be facilitated by nanotechnology. Objective: Synthesis, characterization, statistical …

Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a
macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an …