In response to even a single chromosomal double-strand DNA break, cells enact the DNA
damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to …

Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to
preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased …

Double-strand breaks (DSBs) are potentially lethal DNA lesions that can be repaired by
either homologous recombination (HR) or nonhomologous end-joining (NHEJ). We show …

DNA anaphase bridges are a potential source of genome instability that may lead to
chromosome breakage or nondisjunction during mitosis. Two classes of anaphase bridges …

The current standard of care for malignant gliomas is surgical resection and radiotherapy
followed by extended adjuvant treatment with the alkylating agent temozolomide …

In budding yeast, DNA ends are processed by the consecutive action of MRX/Sae2 and two
redundant pathways dependent on Sgs1/Dna2 and Exo1, and this processing is …

Histone H3 lysine 56 acetylation in Saccharomyces cerevisiae is required for the
maintenance of genome stability under normal conditions and upon DNA replication stress …

Allyl alcohol (AA) is one of the environmental pollutants used as a herbicide and industrial
chemical. AA undergoes enzymatic oxidation in vivo to form Acrolein (Acr), a highly reactive …

Ty1 mobile DNA element is the most abundant and mutagenic retrotransposon present in
the genome of the budding yeast Saccharomyces cerevisiae. Protein regulator of Ty1 …

In many organisms, telomere DNA consists of simple sequence repeat tracts that are
required to protect the chromosome end. In the yeast Saccharomyces cerevisiae, tract …