Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation
Bioelectronic therapies modulating the vagus nerve are promising for cardiovascular,
inflammatory, and mental disorders. Clinical applications are however limited by side-effects …
inflammatory, and mental disorders. Clinical applications are however limited by side-effects …
Computational Modeling of Autonomic Nerve Stimulation: Vagus et al.
Computational models of electrical stimulation, block and recording of autonomic nerves
enable analysis of mechanisms of action underlying neural responses and design of …
enable analysis of mechanisms of action underlying neural responses and design of …
[HTML][HTML] kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents
Background Vagal reflexes regulate homeostasis in visceral organs and systems through
afferent and efferent neurons and nerve fibers. Small, unmyelinated, C-type afferents …
afferent and efferent neurons and nerve fibers. Small, unmyelinated, C-type afferents …
Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans
Objective. We demonstrated how automated simulations to characterize electrical nerve
thresholds, a recently published open-source software for modeling stimulation of peripheral …
thresholds, a recently published open-source software for modeling stimulation of peripheral …
A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy …
A Maxion, E Kutafina, MF Dohrn, P Sacré… - Frontiers in …, 2023 - frontiersin.org
Objective Patients with small fiber neuropathy (SFN) suffer from neuropathic pain, which is
still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral …
still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral …
Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces
CD Eiber, SC Payne, NP Biscola… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide
range of conditions, but effective translation requires increasing the efficacy and …
range of conditions, but effective translation requires increasing the efficacy and …
NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies
Electrical stimulation of peripheral nerves has been used in various pathological contexts for
rehabilitation purposes or to alleviate the symptoms of neuropathologies, thus improving the …
rehabilitation purposes or to alleviate the symptoms of neuropathologies, thus improving the …
Laterality, sexual dimorphism, and human vagal projectome heterogeneity shape neuromodulation to vagus nerve stimulation
Neuromodulation by vagus nerve stimulation (VNS) provides therapeutic benefits in multiple
medical conditions, including epilepsy and clinical depression, but underlying mechanisms …
medical conditions, including epilepsy and clinical depression, but underlying mechanisms …
Reverse-engineered models reveal differential membrane properties of autonomic and cutaneous unmyelinated fibers
Unmyelinated C-fibers constitute the vast majority of axons in peripheral nerves and play
key roles in homeostasis and signaling pain. However, little is known about their ion channel …
key roles in homeostasis and signaling pain. However, little is known about their ion channel …
Computational models of compound nerve action potentials: Efficient filter-based methods to quantify effects of tissue conductivities, conduction distance, and nerve …
Background Peripheral nerve recordings can enhance the efficacy of neurostimulation
therapies by providing a feedback signal to adjust stimulation settings for greater efficacy or …
therapies by providing a feedback signal to adjust stimulation settings for greater efficacy or …