Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D
shapes that bind to specific targets. Although some aptamers exist naturally as the ligand …

DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

Directed evolution has proved to be an effective strategy for improving or altering the activity
of biomolecules for industrial, research and therapeutic applications. The evolution of …

Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an
important role in neurodegenerative diseases, however, the interplay between these two …

Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding
inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a …

To dissect secretory traffic, we developed the retention using selective hooks (RUSH)
system. RUSH is a two-state assay based on the reversible interaction of a hook protein …

Protein fusion tags are indispensible tools used to improve recombinant protein expression
yields, enable protein purification, and accelerate the characterization of protein structure …

In response to the rapidly growing field of proteomics, the use of recombinant proteins has
increased greatly in recent years. Recombinant hybrids containing a polypeptide fusion …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

Cellular novelty can emerge when non-functional loci become functional genes in a process
termed de novo gene birth. But how proteins with random amino acid sequences …