Metal ions: The unfading stars of bone regeneration—From bone metabolism regulation to biomaterial applications

Y Luo, H Liu, Y Zhang, Y Liu, S Liu, X Liu… - Biomaterials Science, 2023 - pubs.rsc.org
In recent years, bone regeneration has emerged as a remarkable field that offers promising
guidance for treating bone-related diseases, such as bone defects, bone infections, and …

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

AG Kurian, RK Singh, V Sagar, JH Lee, HW Kim - Nano-Micro Letters, 2024 - Springer
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing
a significant burden on patients and the healthcare system. Conventional therapies, such as …

[HTML][HTML] Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic …

N Mandakhbayar, YS Ji, A El-Fiqi, KD Patel, DS Yoon… - Bioactive Materials, 2024 - Elsevier
Regeneration of pathological wounds, such as diabetic ulcers, poses a significant challenge
in clinical settings, despite the widespread use of drugs. To overcome clinical side effects …

Multifunctional molybdenum-based nanoclusters engineered gelatin methacryloyl as in situ photo-cross-linkable hybrid hydrogel dressings for enhanced wound …

AG Kurian, N Mandakhbayar, RK Singh… - … Applied Materials & …, 2024 - ACS Publications
Skin injuries and wounds present significant clinical challenges, necessitating the
development of advanced wound dressings for efficient wound healing and tissue …

Coordinated Biophysical Stimulation of MSCs via Electromagnetized Au‐Nanofiber Matrix Regulates Cytoskeletal‐to‐Nuclear Mechanoresponses and Lineage …

RK Singh, AG Kurian, V Sagar, I Park… - Advanced Functional …, 2023 - Wiley Online Library
Biophysical stimulation regulates stem cell functions, including proliferation and
differentiation. Matrix nanotopography and external forces, such as electromagnetic fields …

Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres

G Zuo, P Zhuang, X Yang, Q Jia, Z Cai, J Qi… - Advanced …, 2024 - Wiley Online Library
Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to
osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is the key to the …

[HTML][HTML] Multifunctional dendrimer@ nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses

AG Kurian, N Mandakhbayar, RK Singh, JH Lee… - Materials Today Bio, 2023 - Elsevier
Bone defects in patients entail the microenvironment that needs to boost the functions of
stem cells (eg, proliferation, migration, and differentiation) while alleviating severe …

[HTML][HTML] The exosomal secretomes of mesenchymal stem cells extracted via 3D-printed lithium-doped calcium silicate scaffolds promote osteochondral regeneration

TL Lin, YH Lin, AKX Lee, TY Kuo, CY Chen, KH Chen… - Materials Today Bio, 2023 - Elsevier
The development of surface modification techniques has brought about a major paradigm
shift in the clinical applications of bone tissue regeneration. Biofabrication strategies enable …

Nanozymes With Osteochondral Regenerative Effects: An Overview of Mechanisms and Recent Applications

X Sun, X Xu, X Yue, T Wang, Z Wang… - Advanced …, 2024 - Wiley Online Library
With the discovery of the intrinsic enzyme‐like activity of metal oxides, nanozymes garner
significant attention due to their superior characteristics, such as low cost, high stability, multi …

[HTML][HTML] Biomaterials Designed to Modulate Reactive Oxygen Species for Enhanced Bone Regeneration in Diabetic Conditions

M Li, Z Zhao, J Yi - Journal of functional biomaterials, 2024 - mdpi.com
Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress,
engendering a spectrum of complications, notably increased bone vulnerability. The genesis …