Nanotechnology has shown great promise in unraveling several important issues of
conventional anticancer chemotherapy. Expectations project that a new generation of …

The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a
brief outlook on the metallocene compounds as antitumor drugs as well as the future …

Platinum-based anticancer drugs currently available in the market are associated with
severe side effects. Therefore, extensive research has been performed to design and …

For more than 100 years metal complexes have been extensively used in therapy and since
the discovery of cisplatin the research in this field has expanded exponentially. The scientific …

The matrix metalloproteinases (MMPs) are a family of proteases which are normally up-
regulated in tumor tissues. Gelatin is a biocompatible and non-immunogenic substrate …

A series of nanomaterials based on mesoporous silica have been synthesised and
functionalised with a photoactive polypyridyl ruthenium (II) complex, namely [Ru (bipy) 2 …

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with
potential applications in different therapeutic areas and that have been extensively used as …

The main reasons for the limited clinical efficacy of the platinum (II)-based agent cisplatin
include drug resistance and significant side effects. Due to their better stability, as well as the …

Molecular imaging is an important part of modern medicine which enables the non-invasive
identification and characterization of diseases. With the advancement of radiochemistry and …

Titanium (IV) coordination complexes represent attractive alternatives to platinumbased
anticancer drugs. The advantage of the titanium metal lies in its low toxicity, and the …