Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

Deregulated cell proliferation is an established feature of cancer, and altered tumor
metabolism has witnessed renewed interest over the past decade, including the study of …

Background The metabolic effect of intratumor cholesteryl ester (CE) in breast cancer
remains poorly understood. The objective was to analyze the relationship between …

Breast cancer is the most prevalent cancer and primary cause of cancer-related mortality in
women. The identification of risk factors can improve prevention of cancer, and obesity and …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

High-density lipoprotein (HDL) and its main protein component apolipoprotein (apo) AI, play
an important role in cholesterol homeostasis. It has been demonstrated that HDLs comprise …

Background Resistance to cell death, a protective mechanism for removing damaged cells,
is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to …

Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within
the body. While much work has been done to develop synthetic nanocarriers to deliver …

Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of
cholesterol metabolism contributes to the pathogenesis of various diseases including …