Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas

HM Said - … Journal of Physiology-Gastrointestinal and Liver …, 2013 - journals.physiology.org
This review focuses on recent advances in our understanding of the mechanisms and
regulation of water-soluble vitamin (WSV) transport in the large intestine and pancreas, two …

Targeting endoplasmic reticulum stress as an effective treatment for alcoholic pancreatitis

H Li, W Wen, J Luo - Biomedicines, 2022 - mdpi.com
Pancreatitis and alcoholic pancreatitis are serious health concerns with an urgent need for
effective treatment strategies. Alcohol is a known etiological factor for pancreatitis, including …

Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport

VS Subramanian, SB Subramanya… - … of Physiology-Cell …, 2013 - journals.physiology.org
Vitamin B2 (riboflavin, RF) is essential for normal human health. Mammals obtain RF from
exogenous sources via intestinal absorption and prevent its urinary loss by reabsorption in …

Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): studies utilizing human and mouse colonic preparations

JS Kumar, VS Subramanian… - American Journal …, 2013 - journals.physiology.org
Niacin (vitamin B3; nicotinic acid) plays an important role in maintaining redox state of cells
and is obtained from endogenous and exogenous sources. The latter source has generally …

Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models

VS Subramanian, SB Subramanya… - American Journal of …, 2012 - journals.physiology.org
Thiamin is essential for normal function of pancreatic acinar cells, and its deficiency leads to
a reduction in pancreatic digestive enzymes. We have recently shown that thiamin uptake by …

miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells

K Ramamoorthy, S Sabui, KI Manzon… - American Journal …, 2023 - journals.physiology.org
Thiamin (vitamin B1) plays a vital role in cellular energy metabolism/ATP production.
Pancreatic acinar cells (PACs) obtain thiamin from circulation and convert it to thiamin …

Effect of the cigarette smoke component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on physiological and molecular parameters of thiamin uptake by …

P Srinivasan, VS Subramanian, HM Said - PloS one, 2013 - journals.plos.org
Thiamin is indispensable for the normal function of pancreatic acinar cells. These cells take
up thiamin via specific carrier-mediated process that involves thiamin transporter-1 and-2 …

Chronic alcohol exposure affects pancreatic acinar mitochondrial thiamin pyrophosphate uptake: studies with mouse 266-6 cell line and primary cells

P Srinivasan, S Nabokina… - American Journal of …, 2015 - journals.physiology.org
Thiamin is essential for normal metabolic activity of all mammalian cells, including those of
the pancreas. Cells obtain thiamin from their surroundings and enzymatically convert it into …

Effect of clinical mutations on functionality of the human riboflavin transporter-2 (hRFT-2)

SM Nabokina, VS Subramanian, HM Said - Molecular genetics and …, 2012 - Elsevier
The Brown–Vialetto–Van Laere syndrome (BVVLS) is a rare neurological disease
characterized by ponto-bulbar palsy, bilateral sensorineural deafness, and respiratory …

Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism (s)

KY Anandam, P Srinivasan… - American Journal …, 2021 - journals.physiology.org
Thiamin (vitamin B1) plays critical roles in normal metabolism and function of all mammalian
cells. Pancreatic acinar cells (PACs) import thiamin from circulation via specific carrier …