Update on TB vaccine pipeline

C Martin, N Aguilo, D Marinova, J Gonzalo-Asensio - Applied Sciences, 2020 - mdpi.com
In addition to antibiotics, vaccination is considered among the most efficacious methods in
the control and the potential eradication of infectious diseases. New safe and effective …

Four-gene pan-African blood signature predicts progression to tuberculosis

S Suliman, EG Thompson, J Sutherland… - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …

Automatic cough classification for tuberculosis screening in a real-world environment

M Pahar, M Klopper, B Reeve, R Warren… - Physiological …, 2021 - iopscience.iop.org
Objective. The automatic discrimination between the coughing sounds produced by patients
with tuberculosis (TB) and those produced by patients with other lung ailments. Approach …

Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection

J Nemeth, GS Olson, AC Rothchild, AN Jahn… - PLoS …, 2020 - journals.plos.org
Progress in tuberculosis vaccine development is hampered by an incomplete understanding
of the immune mechanisms that protect against infection with Mycobacterium tuberculosis …

A mathematical model of tuberculosis (TB) transmission with children and adults groups: Afractional model

MA Khan, E Bonyah, Z Hammouch… - AIMS …, 2020 - repository.unair.ac.id
We consider a novel fractional model to investigates the (tuberculosis) TB model dynamics
with two age groups of human, that is, the children and the adults. First, we formulate the …

First-in-human trials of GamTBvac, a recombinant subunit tuberculosis vaccine candidate: safety and immunogenicity assessment

DV Vasina, DA Kleymenov, VA Manuylov… - Vaccines, 2019 - mdpi.com
Tuberculosis is known to be the biggest global health problem, causing the most deaths by a
single infectious agent. Vaccine-development efforts are extremely important. This paper …

[HTML][HTML] Mathematical analysis of a two-strain disease model with amplification

MA Kuddus, ES McBryde, AI Adekunle, LJ White… - Chaos, Solitons & …, 2021 - Elsevier
We investigate a two-strain disease model with amplification to simulate the prevalence of
drug-susceptible (s) and drug-resistant (m) disease strains. Drug resistance first emerges …

Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls

S Suliman, A Gela, SC Mendelsohn… - The Journal of …, 2020 - academic.oup.com
Background In human blood, mucosal-associated invariant T (MAIT) cells are abundant T
cells that recognize antigens presented on non-polymorphic major histocompatibility …

Transmission, distribution and drug resistance-conferring mutations of extensively drug-resistant tuberculosis in the Western Cape Province, South Africa

S Oostvogels, SD Ley, TH Heupink… - Microbial …, 2022 - microbiologyresearch.org
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid
(INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is …

Molecular investigations of Mycobacterium tuberculosis genotypes among baseline and follow-up strains circulating in four regions of Eswatini

TC Dlamini, BT Mkhize, C Sydney, NE Maningi… - BMC Infectious …, 2023 - Springer
Background The tuberculosis (TB) epidemic remains a major global health problem and
Eswatini is not excluded. Our study investigated the circulating genotypes in Eswatini and …