Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently
attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates …

Stroke continues to be the third-leading cause of death and disability worldwide. The limited
availability of diagnostic tools approved therapeutics and biomarkers that help monitor …

Diet is of major importance in modulating intestinal inflammation, as the gastrointestinal tract
is directly exposed to high concentrations of dietary components. Procyanidins are flavan-3 …

The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …

Stroke is classified into two main groups depending on its aetiology; ischaemic stroke and
haemorrhagic stroke which successively develop from the occlusion or rupture of an artery …

Ischemic stroke continues to be a leading cause of mortality and morbidity in the world.
Despite recent advances in the field of stroke medicine, thrombolysis with recombinant …

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB)
integrity through a complex mechanism involving activation of both RhoA/Rho …

Stroke continues to be one of the leading causes of mortality and morbidity worldwide.
Restoration of cerebral blood flow by recombinant plasminogen activator (rtPA) with or …

Intestinal permeabilization is central to the pathophysiology of chronic gut inflammation. This
study investigated the efficacy of glucoraphanin (GR), prevalent in cruciferous vegetables …

Ischemic stroke represents a major cause of adult death and severe neurological disability
worldwide. Reperfusion following brain ischemia produces an inflammatory cascade that …