Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …

This review provides a concise overview of the cellular and clinical aspects of the role of
zinc, an essential micronutrient, in human physiology and discusses zinc-related …

The neuronal ceroid lipofuscinoses (NCL) are a group of disorders defined by shared
clinical and pathological features, including seizures and progressive decline in vision …

Changes in cellular free Zn2+ concentration, including those in the sarco (endo) plasmic
reticulum [S (E) R], are primarily coordinated by Zn2+ transporters (ZnTs) whose identity and …

Skin is the first area that manifests zinc deficiency. However, the molecular mechanisms by
which zinc homeostasis affects skin development remain largely unknown. Here, we show …

A general principle in all cells in the body is that an essential metal–here copper–is taken up
at the plasma membrane, directed through cellular compartments for use in specific …

Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic
processes that lead to abnormally high levels of blood glucose. Preceding the development …

Zinc plays an important role in biological systems as bound and histochemically reactive
labile Zn2+. Although Zn2+ concentration is in the nM range in cardiomyocytes at rest and …