Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …

Sepsis is a disease characterized by multiple organ failure caused by immune
hyperactivation and cytokine storms. Studies have shown that the incidence of sepsis in …

Nicotinamide adenine dinucleotide (NAD+) is indispensable for the anti-aging activity of the
sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD+ …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Recent attention has focused on the use of extracellular vesicles (EVs) as biological
indicators of health and disease. These small, nano-sized membrane bound vesicles are …

MiR-27b is highly expressed in endothelial cells (EC) but its function in this context is poorly
characterized. This study aims to investigate the effect of miR-27b on inflammatory …

The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains
unclear. A total of 430 participants were recruited for the screening of differentially …

Colon cancer etiology involves a wide spectrum of genetic and epigenetic alterations,
finding it challenging to find effective therapeutic strategies. Quercetin exhibits potent anti …

Background The intervertebral disc (IVD) degeneration is the leading cause of low back
pain, which accounts for a main cause of disability. N6‐methyladenosine (m6A) is the most …