Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with
atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating TMAO …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

Enterohepatic circulation serves to capture bile acids and other steroid metabolites
produced in the liver and secreted to the intestine, for reabsorption back into the circulation …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …

Rationale: The bile acid receptor farnesoid X receptor (FXR) regulates many aspects of lipid
metabolism by variouscomplex and incompletely understood molecular mechanisms. We …

Bile acids (BAs) are amphipathic molecules produced from cholesterol by the liver. Expelled
from the gallbladder upon meal ingestion, BAs serve as fat solubilizers in the intestine. BAs …

Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …

Context: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known
agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid …