Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …

Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads
to the production of the oncometabolite 2-R-2-hydroxyglutarate (2-HG). In six model …

Glioblastoma (GBM) is one of the most aggressive and lethal tumor types. Evidence
continues to accrue indicating that the complex relationship between GBM and the brain …

Purpose: The goal of this study is to enhance the efficacy of imipridones, a novel class of
AKT/ERK inhibitors that displayed limited therapeutic efficacy against glioblastoma (GBM) …

Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …

Dopamine receptors are belong to the family of G protein-coupled receptor. There are five
types of dopamine receptor (DR), including DRD1, DRD2, DRD3, DRD4, and DRD5, which …

Psychotropic drugs can penetrate the blood–brain barrier and regulate the levels of
neurotransmitters and neuromodulators such as γ-aminobutyric acid, glutamate, serotonin …

The nervous system is viewed as a tissue affected by cancer and as a conduit for the
transmission of cancer pain and perineural invasion. Here, we review recent studies that …

Glioblastoma (GBM) is characterized by extremely poor prognoses, despite the use of gross
surgical resection, alkylating chemotherapeutic agents, and radiotherapy. Evidence …

Malignant gliomas are still extremely difficult to treat because complete surgical resection is
biologically not feasible due to the invasive nature of these diseases and the proximity of …