Aetiology of biliary atresia: what is actually known?

C Petersen, M Davenport - Orphanet journal of rare diseases, 2013 - Springer
Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even
when there has been timely diagnosis and exemplary surgery. It has been the commonest …

The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease

CL Mack - Seminars in liver disease, 2007 - thieme-connect.com
Biliary atresia is a mystifying cause of neonatal cholestasis, manifested by progressive
inflammation and fibrosis of both the extrahepatic and intrahepatic bile ducts. It is a …

Cytomegalovirus-associated biliary atresia: An aetiological and prognostic subgroup

A Zani, A Quaglia, N Hadzić, M Zuckerman… - Journal of pediatric …, 2015 - Elsevier
Background and aims Perinatal cytomegalovirus (CMV) infection is a possible cause or
trigger of biliary atresia though clinical evidence is scant. We hypothesised that CMV IgM+ …

[PDF][PDF] Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study

KB Schwarz, BH Haber, P Rosenthal, CL Mack… - …, 2013 - Wiley Online Library
The etiology of biliary atresia (BA) is unknown. Given that patterns of anomalies might
provide etiopathogenetic clues, we used data from the North American Childhood Liver …

[PDF][PDF] Cytomegalovirus‐specific T‐cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells

SM Brindley, AM Lanham, FM Karrer, RM Tucker… - …, 2012 - Wiley Online Library
Biliary atresia (BA) is a progressive, inflammatory cholangiopathy that culminates in fibrosis
of extrahepatic and intrahepatic bile ducts. A leading theory on the pathogenesis of BA is …

Incidence of hepatotropic viruses in biliary atresia

S Rauschenfels, M Krassmann, AN Al-Masri… - European journal of …, 2009 - Springer
Biliary atresia (BA) is the most frequent indication for paediatric liver transplantation. We
tested the hypothesis of a viral aetiology of this disease by screening liver samples of a large …

The perinatal infection of cytomegalovirus is an important etiology for biliary atresia in China

Y Xu, J Yu, R Zhang, Y Yin, J Ye, L Tan… - Clinical …, 2012 - journals.sagepub.com
Aims. The aims of this study were to detect the infection rates of DNA viruses in liver tissue of
biliary atresia and to investigate the effect of perinatal infection of cytomegalovirus in biliary …

[HTML][HTML] Evidence for viral induction of biliary atresia: a review

LD Averbukh, GY Wu - Journal of clinical and translational …, 2018 - ncbi.nlm.nih.gov
Biliary atresia (BA) is a childhood disease which manifests with abnormal narrowing,
blockage or complete absence of bile ducts within the liver. Many possible etiologies have …

Adjuvant therapy of cytomegalovirus IgM+ ve associated biliary atresia: Prima facie evidence of effect

F Parolini, N Hadzic, M Davenport - Journal of Pediatric Surgery, 2019 - Elsevier
Aim of study CMV-IgM+ ve associated biliary atresia (CMV-BA) is a distinct etiological
subgroup characterized by older age at presentation and a greater degree of inflammation …

Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

R Hill, A Quaglia, M Hussain, N Hadzic… - Journal of pediatric …, 2015 - Elsevier
Background Biliary atresia (BA), a cholangiopathy of unknown etiology is associated with
intrahepatic mononuclear cell infiltrate. An abnormal reaction to viral exposure has been …