Osteoarthritis (OA), the most common musculoskeletal disease in the United States, is
characterized by cartilage breakdown, pain, and restricted movement. Post‐traumatic OA …

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA)
pathogenesis, little is known about local changes in bone structure compared to cartilage …

Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites
at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses …

Relationships between composition, structure and constituent-specific functional properties
of human articular cartilage at different stages of osteoarthritis (OA) are poorly known. We …

This study investigates the influence of osteoarthritis (OA) disease severity on the bio-
composition of the osteochondral junction at the human tibial plateau using Raman …

In this study, fibril-reinforced poroelastic (FRPE) modeling was used for rabbit knee after
anterior cruciate ligament transection (ACLT) to assess how the mechanical properties of …

Objective Advances in research have shown that the subchondral bone plays an important
role in the propagation of cartilage loss and progression of osteoarthritis (OA), but whether …

Osteoarthritis (OA) is one of the most common chronic diseases and characterized by
degradation of articular cartilage. We have previously reported xanthan gum (XG) injection …

Subchondral bone structure has been observed to change in osteoarthritis (OA). However, it
remains unclear how the early-stage OA changes affect the mechanics (stresses and …

Posttraumatic fibrotic scarring is a significant medical problem that alters the proper
functioning of injured tissues. Current methods to reduce posttraumatic fibrosis rely on anti …