Enzymes are the core for biological transformations in nature. Their structures and functions
have drawn enormous attention from biologists as well as chemists since last century. The …

Epoxidation of alkenes is a significant reaction in organic chemistry due to its opportunities
in producing compounds of biochemical interest. Catalytic epoxidation with first‐row …

This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Allenone has been identified as a highly effective peptide coupling reagent for the first time.
The peptide bond was formed with an α-carbonyl vinyl ester as the key intermediate, the …

Pharmaceutical production remains one of the last industries that predominantly uses batch
processes, which are inefficient and can cause drug shortages due to the long lead times or …

A novel ynamide coupling reagent, the by-product of which can be removed by water, was
reported. It promotes the direct coupling between carboxylic acids and amines, alcohols or …

There is no precedent for the usage of transition metal carbamoyl complexes (typical
hydrogenase models) as pre-catalysts for oxidation or CO 2 utilization purposes. In this …

This article describes the process characterization and development of models to inform a
process control strategy to prepare (R, R)-epoxy ketone 2, an intermediate in the …

Developing approaches to predictably selective functionalization of aliphatic C–H bonds has
long been one of the major challenges (“Holy grails”, Bergman, Acc. Chem. Res. 28 (1995) …

The development of a photochemical bromination/alkylation sequence as part of a
continuous process for the synthesis of an intermediate en route to AMG 423 is discussed …