The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can
potentially be accomplished using the processes of dedifferentiation, transdifferentiation or …

There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

A progressive reduction in β‐cell mass occurs in the evolution of diabetes. Thus
understanding the mechanisms responsible for this reduction in β‐cell mass is important for …

Background The development of colorectal cancer (CRC) is accompanied by extensive
epigenetic changes, including frequent regional hypermethylation particularly of gene …

O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of nuclear and cytoplasmic
proteins is important for many cellular processes, and the number of proteins that contain …

Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its
mass while sustaining essential metabolic functions. How the liver balances dual demands …

Type 2 diabetes (T2D) is a disorder of complex genetics influenced by interactions between
susceptible genetic loci and environmental perturbations. Intrauterine growth retardation is …

OBJECTIVE NEUROD1 is expressed in both developing and mature β-cells. Studies in mice
suggest that this basic helix-loop-helix transcription factor is critical in the development of …

The prevalence of diabetes and its related complications are increasing significantly
globally. Collected evidence suggested that several genetic and environmental factors …

The role of the adipocyte-derived factor visfatin in metabolism remains controversial,
although some pancreatic β-cell-specific effects have been reported. This study investigated …