Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein
FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Introduction: Irisin is a myokine considered to be a potential mediator of exercise-induced
energy metabolism and its secretion is known to promote the browning of beige fat cells in …

Physical exercise may activate a number of important biochemical processes in the human
body. The aim of this systematic review and meta-analysis was to identify the long-term …

Irisin (IR) is a biomarker that is associated with metabolic syndrome (MetS). However, the
available evidence on the association of IR, physical activity, and MetS status are …

Frailty is a complex condition that emerges from dysregulation in multiple physiological
systems. Increasing evidence suggests the potential role of age-related energy …

Osteoarthritis is a chronic degenerative musculoskeletal disease characterized by
pathological changes in joint structures along with the incidence of which increases with …

Background Exerkines are all peptides, metabolites, and nucleic acids released into the
bloodstream during and after physical exercise. Exerkines liberated from skeletal muscle …

Muscle and adipose tissue produce irisin during exercise. Irisin is thermogenic
adipomyokine, improves glucose and lipid metabolism, and ameliorates the effects of …