The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …

The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that
is used by the cell to perform reverse membrane scission in essential processes like protein …

Endosomal sorting complexes for transport-III (ESCRT-III) assemble in vivo onto membranes
with negative Gaussian curvature. How membrane shape influences ESCRT-III …

Both natural as well as artificial vesicles are of tremendous interest in biology and
nanomedicine. Small vesicles (< 200 nm) perform essential functions in cell biology and …

Despite considerable research efforts, it is still not clear which mechanisms underlie
neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple …

Live-cell imaging has revolutionized our understanding of dynamic cellular processes in
bacteria and eukaryotes. Although similar techniques have been applied to the study of …

Abscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB)
connecting two daughter cells. Abscission requires tight control of the recruitment and …

Background The interest in mechanics of synthetic and biological vesicles has been
continuously growing during the last decades. Liposomes serve as model systems for …

Background The optimal diagnosis and treatment of tuberculosis (TB) are challenging due to
underdiagnosis and inadequate treatment monitoring. Lipid-related genes are crucial …

The mechanical properties of biological nanoparticles play a crucial role in their interaction
with the cellular membrane, in particular for cellular uptake. This has significant implications …