[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs

OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

M Ostaszewski, A Niarakis, A Mazein… - Molecular systems …, 2021 - embopress.org
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds

P Khanal, VS Patil, VV Bhandare, PSR Dwivedi… - Computers in Biology …, 2022 - Elsevier
Benzalacetophenones, precursors of flavonoids are aromatic ketones and enones and
possess the immunostimulant as well as antiviral activities. Thus, benzalacetophenones …

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

A Samy, MA Maher, NA Abdelsalam, E Badr - Scientific Reports, 2022 - nature.com
COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus
evolve, a complete comprehension of the disease and drug targets becomes a decisive …

SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-RH): role of Fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in …

SAG Naidu, RA Clemens, AS Naidu - Journal of dietary …, 2023 - Taylor & Francis
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …

The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections

AJ Kombe Kombe, L Fotoohabadi, R Nanduri… - International journal of …, 2024 - mdpi.com
Respiratory viruses constitute a significant cause of illness and death worldwide.
Respiratory virus-associated injuries include oxidative stress, ferroptosis, inflammation …

[HTML][HTML] From cell to symptoms: The role of SARS-CoV-2 cytopathic effects in the pathogenesis of COVID-19 and long COVID

P Gonzalez-Garcia, O Fiorillo Moreno… - International Journal of …, 2023 - mdpi.com
Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection triggers various
events from molecular to tissue level, which in turn is given by the intrinsic characteristics of …

[HTML][HTML] The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications

RD Singh, MA Barry, AJ Croatt, AW Ackerman… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Background Acute kidney injury (AKI) is both a consequence and determinant of outcomes
in COVID-19. The kidney is one of the major organs infected by the causative virus, SARS …

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

AS Naidu, CK Wang, P Rao, F Mancini… - npj Science of …, 2024 - nature.com
Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …