Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation

MR Gaddem, J Kim, K Matsunami, Y Hayashi… - Current Opinion in …, 2024 - Elsevier
This work presents a bird's eye view depicting current trends in the pharmaceutical industry
and the role of mathematical modeling in process design and operation within the …

Image‐based hybrid model incorporating initial spatial distribution for mesenchymal stem cell cultivation process design

K Hirono, Y Hayashi, I A. Udugama, Y Takemoto… - AIChE …, 2024 - Wiley Online Library
This work presents an image‐based hybrid model incorporating the initial spatial distribution
for mesenchymal stem cell (MSC) cultivation process design. First, three levels of seeding …

[HTML][HTML] Spatial heterogeneity analysis of seeding of human induced pluripotent stem cells for neuroectodermal differentiation

AAI Qatan, S Tanbara, M Inamori, K Fukumori… - Regenerative …, 2024 - Elsevier
Introduction Preparing a uniform cell population in high–density seeding of adherent human
induced pluripotent stem cells (hiPSC) requires stable culture conditions and consistent …