Maternal-fetal pharmacology of drugs: a review of current status of the application of physiologically based pharmacokinetic models
Pregnancy and the postpartum period are associated with several physiological changes
that can alter the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs. For certain …
that can alter the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs. For certain …
Health effects of naphthalene exposure: a systematic evidence map and analysis of potential considerations for dose–response evaluation
EE Yost, A Galizia, DF Kapraun… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Naphthalene is a polycyclic aromatic hydrocarbon that has been associated
with health effects, including cancer. As the state of the science on naphthalene toxicity …
with health effects, including cancer. As the state of the science on naphthalene toxicity …
Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models
Y Zhu, X Pan, Y Jia, X Yang, X Song… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Oral ingestion, inhalation, and skin contact are important exposure routes for
humans to uptake per-and polyfluoroalkyl substances (PFAS). However, nasal and dermal …
humans to uptake per-and polyfluoroalkyl substances (PFAS). However, nasal and dermal …
Physiologically-based toxicokinetic modeling of human dermal exposure to diethyl phthalate: Application to health risk assessment
M Hu, Y Zhang, M Zhan, G He, W Qu, Y Zhou - Chemosphere, 2022 - Elsevier
Diethyl phthalate (DEP) has been most frequently detected in personal care products
(PCPs) as a solvent followed by indoor air as one of the semi-volatile organic compounds …
(PCPs) as a solvent followed by indoor air as one of the semi-volatile organic compounds …
Development of human dermal PBPK models for the bisphenols BPA, BPS, BPF, and BPAF with parallel-layered skin compartment: basing on dermal administration …
M Hu, Z Zhang, Y Zhang, M Zhan, W Qu, G He… - Science of The Total …, 2023 - Elsevier
Risk assessment of human exposure to bisphenols (BPs) including bisphenol A, S, F and AF
(BPA, BPS, BPF and BPAF) have suggested that except for ingestion, health risk resulting …
(BPA, BPS, BPF and BPAF) have suggested that except for ingestion, health risk resulting …
Bayesian pbpk modeling using r/stan/torsten and julia/sciml/turing. jl
A Elmokadem, Y Zhang, T Knab… - CPT …, 2023 - Wiley Online Library
Physiologically‐based pharmacokinetic (PBPK) models are mechanistic models that are
built based on an investigator's prior knowledge of the in vivo system of interest. Bayesian …
built based on an investigator's prior knowledge of the in vivo system of interest. Bayesian …
Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population
Z Zhang, M Hu, D Xuan, L Wu, Y Zhang, G He… - Food and Chemical …, 2022 - Elsevier
The wide usage of decabromodiphenyl ether (BDE-209) as additive brominated flame
retardant has caused its widespread occurrence in the environment and high exposure risk …
retardant has caused its widespread occurrence in the environment and high exposure risk …
Conventional and alternative aviation fuels: occupational exposure and health effects
N Karanikas, C Foster… - ACS Chemical Health …, 2021 - ACS Publications
The use of fossil fuels in aircraft over the last few decades has driven several studies on
health effects due to occupational exposure. Relatively recently, alternative fuel types have …
health effects due to occupational exposure. Relatively recently, alternative fuel types have …
[PDF][PDF] Symbolic PBPK-PDE Modeling Using Open-Source Julia Tools
Objectives: Physiologically based pharmacokinetic (PBPK) models provide a mechanistic
characterization of a drug's distribution in the body. Ordinary differential equations (ODEs) …
characterization of a drug's distribution in the body. Ordinary differential equations (ODEs) …