Gastrointestinal dysfunction in Parkinson's disease: molecular pathology and implications of gut microbiome, probiotics, and fecal microbiota transplantation

V Metta, V Leta, KR Mrudula, LK Prashanth, V Goyal… - Journal of …, 2022 - Springer
Gastrointestinal symptoms and gut dysbiosis may occur before the onset of motor symptoms
in Parkinson's disease (PD). Prediagnostic and prodromal features, such as constipation …

Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies

B Waclawiková, A Codutti, K Alim, S El Aidy - Gut microbes, 2022 - Taylor & Francis
The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities
have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial …

The physiology and pathophysiology of gastric emptying in humans

H Minami, RW Mccallum - Gastroenterology, 1984 - Elsevier
The past decade has witnessed an exponential growth of knowledge in the field of gastric
motility. The elucidation of the clinical problems of gastric emptying is based on remarkable …

Metoclopramide: an updated review of its pharmacological properties and clinical use

RA Harrington, CW Hamilton, RN Brogden… - Drugs, 1983 - Springer
Synopsis: Since previously reviewed in the Journal (Vol. 12, No. 2), metoclopramide has
been confirmed as an effective drug in treating and preventing various types of vomiting and …

Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.

JA Schuurkes, JM Van Nueten… - The Journal of …, 1985 - jpet.aspetjournals.org
The effects of cisapride (R 51619), a new non-dopamine-blocking gastrokinetic drug, on
gastrointestinal contractility have been determined on isolated preparations of the guinea …

Parkinson's disease medication alters small intestinal motility and microbiota composition in healthy rats

SP van Kessel, A Bullock, G van Dijk, S El Aidy - Msystems, 2022 - Am Soc Microbiol
Parkinson's disease (PD) is known to be associated with altered gastrointestinal function
and microbiota composition. To date, the effect of PD medication on the gastrointestinal …

Gastrointestinal dysfunction in Parkinson's disease

D Safarpour, K Sharzehi, RF Pfeiffer - Drugs, 2022 - Springer
There has been exponential growth in the awareness and understanding of gastrointestinal
(GI) dysfunction in Parkinson's disease (PD) over the past 3 decades. The clinical features of …

Antivenom efficacy or effectiveness: the Australian experience

GK Isbister - Toxicology, 2010 - Elsevier
Despite widespread use of antivenoms, many questions remain about their effectiveness in
the clinical setting. The almost universal acceptance of their value is based mainly on in vitro …

Contributions of gut bacteria and diet to drug pharmacokinetics in the treatment of Parkinson's disease

SP Van Kessel, S El Aidy - Frontiers in Neurology, 2019 - frontiersin.org
Parkinson's disease is the second-most common neurodegenerative disorder worldwide.
Besides deciphering the mechanisms that underlie the etiology of the disease, it is important …

Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924.

GJ Sanger - British journal of pharmacology, 1987 - ncbi.nlm.nih.gov
The mechanisms by which BRL 24924 ([(+/-)-(endo)])-4-amino-5-chloro-2-methoxy-N-(1-
azabicyclo-[3.3. 1]-non-4-yl) benzamide hydrochloride stimulates gut motility and the …