The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Pyroptosis is a form of cell death triggered by the innate immune system that has been
implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level …

Conspectus Here we provide a personal account of innovation and design principles
underpinning a method to interrogate precision electrophile signaling that has come to be …

Proximity labeling technologies are limited to indexing localized protein residents. Such data—
although valuable—cannot inform on small-molecule responsivity of local residents. We …

Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of
signaling across different cellular compartments. However, how nonenzymatic PTMs …

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux
attributable to on-target, vis-à-vis off-target, modifications. By combining bolus dosing …

Revolutionary proteomic strategies have enabled rapid profiling of the cellular targets of
electrophilic small molecules. However, precise means to directly interrogate how these …

Transient associations between numerous organelles—eg, the endoplasmic reticulum and
the mitochondria—forge highly-coordinated, particular environments essential for cross …

Precision cell signaling activities of reactive electrophilic species (RES) are arguably among
the most poorly‐understood means to transmit biological messages. Latest research …

Here we discuss, how by applying chemical concepts to biological problems, methods have
been developed to map spatiotemporal regulation of proteins and small-molecule …