Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

Suicide is a complex public health problem of global importance. Suicidal behaviour differs
between sexes, age groups, geographic regions, and sociopolitical settings, and variably …

Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Early-life adversity increases the risk for psychopathology in later life. The underlying
mechanism (s) is unknown, but epigenetic variation represents a plausible candidate. Early …

Brain-derived neurotrophic factor (BDNF) regulates the survival and growth of neurons, and
influences synaptic efficiency and plasticity. The human BDNF gene consists of 11 exons …

Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings.
The authors review and synthesize the research literature on biomarkers of suicide, with the …

Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …