The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …

DNA damage poses a serious threat to human health and cells therefore continuously
monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain …

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical
management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX …

Abstract Multifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays
important roles in nuclease-mediated DNA repair and redox regulation in transcription …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

Nucleoli are the major cellular compartments for the synthesis of rRNA and assembly of
ribosomes, the macromolecular complexes responsible for protein synthesis. Given the …

Abstract p53-mutated tumors often exhibit increased resistance to standard chemotherapy
and enhanced metastatic potential. Here we demonstrate that inhibition of dihydroorotate …

Due to their exceptional simplicity of organization, viruses rely on the resources, molecular
mechanisms, macromolecular complexes, regulatory pathways, and functional …

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …

In response to genotoxic stress‐induced DNA damage, TopBP1 mediates ATR activation for
signaling transduction and DNA damage repair. However, the detailed molecular …