Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

The incidence of acute pancreatitis (AP) is increasing globally and mortality could be high
among patients with organ failure and infected necrosis. The predominant factors …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Recent studies have highlighted the importance of autophagy and particularly non-
canonical autophagy in the development and progression of acute pancreatitis (a frequent …

Purpose of the review: Pancreatic cancer is extremely aggressive, forming highly chemo-
resistant tumors, and has one of the worst prognoses. The evolution of this cancer is multi …

Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific
therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The …

Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A
proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes …