Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …
Hepatocellular carcinoma (primer)
JM Llovet, RK Kelley, A Villanueva… - Nature Reviews …, 2021 - search.proquest.com
Liver cancer remains a global health challenge, with an estimated incidence of> 1 million
cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer …
cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer …
[HTML][HTML] Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
D Du, C Liu, M Qin, X Zhang, T Xi, S Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …
Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development
Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …
A researcher's guide to preclinical mouse NASH models
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis
Background & Aims Regulatory T-cells (Tregs) impair cancer immunosurveillance by
creating an immunosuppressive environment that fosters tumor cell survival. Our previous …
creating an immunosuppressive environment that fosters tumor cell survival. Our previous …
[HTML][HTML] Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH
Background & Aims Previous single-cell RNA-sequencing analyses have shown that Trem2-
expressing macrophages are present in the liver during obesity, non-alcoholic …
expressing macrophages are present in the liver during obesity, non-alcoholic …
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …