Amino acids are attractive and promising biochemicals with market capacity requirements
constantly increasing. Their applicability ranges from animal feed additives, flavour …

Metabolic engineering has been enabling development of high performance microbial
strains for the efficient production of natural and non-natural compounds from renewable …

The production of aromatic amino acids using fermentation processes with recombinant
microorganisms can be an advantageous approach to reach their global demands. In …

Efficient biosynthesis of l-tyrosine from glucose is necessary to make biological production
economically viable. To this end, we designed and constructed a modular biosynthetic …

Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

During metabolic evolution to improve succinate production in Escherichia coli strains,
significant changes in cellular metabolism were acquired that increased energy efficiency in …

The application of metabolic engineering in Escherichia coli has resulted in the generation
of strains with the capacity to produce metabolites of commercial interest. Biotechnological …

Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir
(Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation …

The excretion of the aromatic amino acid l-tyrosine was achieved by manipulating three
gene targets in the wild-type Escherichia coli K12: The feedback-inhibition-resistant (fbr) …