SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …
Senescence-associated secretory phenotype as a hinge between cardiovascular diseases and cancer
P Banerjee, S Kotla, L Reddy Velatooru… - Frontiers in …, 2021 - frontiersin.org
Overlapping risks for cancer and cardiovascular diseases (CVD), the two leading causes of
mortality worldwide, suggest a shared biology between these diseases. The role of …
mortality worldwide, suggest a shared biology between these diseases. The role of …
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain
J Li, M Tian, T Hua, H Wang, M Yang, W Li, X Zhang… - Autophagy, 2021 - Taylor & Francis
Macroautophagy/autophagy, an evolutionarily conserved process, plays an important role in
the regulation of immune inflammation and nervous system homeostasis. However, the …
the regulation of immune inflammation and nervous system homeostasis. However, the …
[HTML][HTML] Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
WA van der Heijden, L Van de Wijer, F Keramati… - JCI insight, 2021 - ncbi.nlm.nih.gov
Chronic inflammation and immune dysfunction play a key role in the development of non-
AIDS–related comorbidities. The aim of our study was to characterize the functional …
AIDS–related comorbidities. The aim of our study was to characterize the functional …
HIV and cardiovascular disease: the role of inflammation
S Dirajlal-Fargo, N Funderburg - Current Opinion in HIV and AIDS, 2022 - journals.lww.com
Mechanistic studies into the drivers of chronic inflammation in PWH are ongoing and may
aid in tailoring effective therapeutic strategies that can reduce ASCVD risk in this population …
aid in tailoring effective therapeutic strategies that can reduce ASCVD risk in this population …
Radiation-induced cardiovascular disease: mechanisms, prevention, and treatment
Abstract Purpose of Review Despite the advancements of modern radiotherapy, radiation-
induced cardiovascular disease (RICVD) remains a common cause of morbidity and …
induced cardiovascular disease (RICVD) remains a common cause of morbidity and …
An ERK5-NRF2 axis mediates senescence-associated stemness and atherosclerosis
Background: ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …
Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest
Senescent cells release a variety of cytokines, proteases, and growth factors collectively
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …
[HTML][HTML] Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent …
S Kotla, A Zhang, M Imanishi, KA Ko, SH Lin, YJ Gi… - Redox Biology, 2021 - Elsevier
The incidence of cardiovascular disease (CVD) is higher in cancer survivors than in the
general population. Several cancer treatments are recognized as risk factors for CVD, but …
general population. Several cancer treatments are recognized as risk factors for CVD, but …
Aerobic exercise alters the melanoma microenvironment and modulates ERK5 S496 phosphorylation
Exercise changes the tumor microenvironment by remodeling blood vessels and increasing
infiltration by cytotoxic immune cells. The mechanisms driving these changes remain …
infiltration by cytotoxic immune cells. The mechanisms driving these changes remain …