Unraveling the Puzzle of Therapeutic Peptides: A Promising Frontier in Huntington's Disease Treatment

S Ahamad, N Bano, S Khan, MK Hussain… - Journal of Medicinal …, 2024 - ACS Publications
Huntington's disease (HD) is a neurodegenerative genetic disorder characterized by a
mutation in the huntingtin (HTT) gene, resulting in the production of a mutant huntingtin …

The emerging landscape of small-molecule therapeutics for the treatment of Huntington's disease

S Ahamad, SA Bhat - Journal of medicinal chemistry, 2022 - ACS Publications
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG
repeat expansion in the huntingtin gene (HTT). The new insights into HD's cellular and …

Oleuropein enhances proteasomal activity and reduces mutant huntingtin-induced cytotoxicity

ZN Huang, SY Lee, JM Chen, ZT Huang… - Frontiers in …, 2024 - frontiersin.org
Introduction Huntington's disease (HD) is a hereditary neurodegenerative disorder that
primarily affects the striatum, a brain region responsible for movement control. The disease …

[HTML][HTML] Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer's, Parkinson's, and ALS

C Toader, CP Tataru, O Munteanu… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS, and Huntington's,
remain formidable challenges in medicine, with their relentless progression and limited …

Descripción de nuevos correlatos transcripcionales y de nuevas fuentes de biomarcadores en la enfermedad de Huntington

A Gallardo Orihuela - 2023 - rodin.uca.es
Esta tesis se ha centrado en mejorar las estrategias existentes de obtención de
biomarcadores con potencial valor pronóstico en la enfermedad de Huntington (EH), una …

[引用][C] The Huntington's disease drug pipeline: a review of small molecules and their therapeutic targets

S Khan, N Bano, VN Uversky, S Ahamad, SA Bhat - 2024 - Elsevier