Many lines of evidence, ranging from in vitro experiments and pathological examinations to
epidemiological studies, show that inflammation is a cardinal pathogenetic mechanism in …

Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD).
Over the past two decades, there has been significant clarification of the various pathways …

Glomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits,
but their important contribution to the glomerular filtration barrier has not received …

The aim of this study was to investigate the structural characteristics of podocytes and
endothelial cells in diabetic nephropathy. We studied 18 patients with type 1 diabetes …

Diabetes mellitus entails significant health problems worldwide. The pathogenesis of
diabetes is multifactorial, resulting from interactions of both genetic and environmental …

The mechanisms that drive the development of diabetic nephropathy remain undetermined.
Only 30–40% of patients with diabetes mellitus develop overt nephropathy, which suggests …

Microvascular complications are responsible for a major proportion of the burden associated
with diabetes contributing to substantial morbidity, mortality, and healthcare burden in …

The role of podocytes in the development and progression of glomerular disease has been
extensively investigated in the past decade. However, the importance of glomerular …

Activation of innate immunity with the subsequent development of a chronic low-grade
inflammatory response is now recognized as a critical factor in the pathogenesis of diabetes …

We investigated the possible role of reactive oxygen species (ROS) on renal function in
experimental diabetes. MATERIALS AND METHODS: Seven groups of male rats were …