The mechanism of Warburg effect-induced chemoresistance in cancer

C Liu, Y Jin, Z Fan - Frontiers in oncology, 2021 - frontiersin.org
Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …

Molecular mechanisms of drug resistance and its reversal in cancer

M Kartal-Yandim, A Adan-Gokbulut… - Critical reviews in …, 2016 - Taylor & Francis
Chemotherapy is the main strategy for the treatment of cancer. However, the main problem
limiting the success of chemotherapy is the development of multidrug resistance. The …

[HTML][HTML] The impact of tumour pH on cancer progression: strategies for clinical intervention

C Ward, J Meehan, ME Gray, AF Murray… - … of Targeted Anti …, 2020 - ncbi.nlm.nih.gov
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

S Granja, D Tavares-Valente, O Queiros… - Seminars in cancer …, 2017 - Elsevier
Altered metabolism, associated with acidification of the extracellular milieu, is one of the
major features of cancer. As pH regulation is crucial for the maintenance of all biological …

Green synthesis of silver nanoparticles using cell extracts of Anabaena doliolum and screening of its antibacterial and antitumor activity

G Singh, PK Babele, SK Shahi, RP Sinha… - … of Microbiology and …, 2014 - koreascience.kr
In the present work, we describe a simple, cheap, and unexplored method for" green"
synthesis of silver nanoparticles using cell extracts of the cyanobacterium Anabaena …

Links between cancer metabolism and cisplatin resistance

V Cocetta, E Ragazzi, M Montopoli - … review of cell and molecular Biology, 2020 - Elsevier
Cisplatin is one of the most potent and widely used chemotherapeutic agent in the treatment
of several solid tumors, despite the high toxicity and the frequent relapse of patients due to …

Lactate and lactate transporters as key players in the maintenance of the Warburg effect

A Pereira-Nunes, J Afonso, S Granja… - … : the main driver of …, 2020 - Springer
Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells display
a glycolytic phenotype, with increased glucose consumption and glycolysis rates, and …

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells

R Amorim, C Pinheiro, V Miranda-Gonçalves, H Pereira… - Cancer letters, 2015 - Elsevier
Cancer cells rely mostly on glycolysis to meet their energetic demands, producing large
amounts of lactate that are extruded to the tumour microenvironment by monocarboxylate …

A microporous Tb-based MOF for multifunctional detection of the α-CHC, Cu2+ and Fe3+

X Zhang, L Feng, S Ma, T Xia, F Jiao, Z Kong… - Journal of Solid State …, 2022 - Elsevier
Here, we successfully synthesized a Tb-MOF,[Tb 4 (TATB) 2](H 3 TATB​=​ 4, 4′, 4 ″-(1,
3, 5-triazine-2, 4, 6-triyl) tribenzoic acid) used 2-fluorobenzoic acid as the nuclear cluster …

Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma–MCT1 as potential target in diffuse large B cell lymphoma

J Afonso, T Pinto, S Simões-Sousa, F Schmitt… - Cellular oncology, 2019 - Springer
Purpose Increased glycolytic activity with accumulation of extracellular lactate is regarded as
a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic …