Adaptation of bone to mechanical stresses normally produces a bone architecture that
combines a proper resistance against failure with a minimal use of material. This adaptive …

Musculoskeletal injuries are a common cause of lost training days and wastage in
racehorses. Many bone injuries are a consequence of repeated high loading during fast …

Bone is repaired by remodelling, a process influenced by its loading environment. The aim
of this study was to investigate the effect of a change in loading environment on bone …

We question two major tenets of bone biology: that the primary role of remodelling is to
remove damage in the bone (so‐called damage‐driven remodelling) and that osteocytes …

Optimization can be seen in a number of human skeletal bones. While there is strong
evidence concerning the mechanism at the tissue-level for bone adaptation to the applied …

Bone remodelling is carried out by 'bone multicellular units'(BMU s) in which active
osteoclasts and active osteoblasts are spatially and temporally coupled. The refilling of new …

Patient-specific simulations of bone remodelling could enable predicting how bone micro-
structural integrity would be affected by bone diseases, drugs or other factors, and, ultimately …

In racehorses, fatigue related subchondral bone injury leads to overt fracture or articular
surface collapse and subsequent articular cartilage degeneration. We hypothesised that the …

Impaired bone toughness is increasingly recognized as a contributor to fragility fractures. At
the tissue level, toughness is related to the ability of bone tissue to resist the development of …

Adaptation is the process by which bone responds to changes in loading environment and
modulates its properties and spatial organization to meet the mechanical demands …