Evolution of microRNA diversity and regulation in animals
E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts
JA Wallace, RM O'Connell - … Journal of the American Society of …, 2017 - ashpublications.org
Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …
miRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis–associated genes
M Croset, F Pantano, CWS Kan, E Bonnelye… - Cancer research, 2018 - AACR
Abstract miRNAs are master regulators of gene expression that play key roles in cancer
metastasis. During bone metastasis, metastatic tumor cells must rewire their biology and …
metastasis. During bone metastasis, metastatic tumor cells must rewire their biology and …
Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease
J Ren, J Zhang, N Xu, G Han, Q Geng, J Song, S Li… - PloS one, 2013 - journals.plos.org
Aims MicroRNAs (miRNAs) play important roles in the pathogenesis of cardiovascular
diseases. Circulating miRNAs were recently identified as biomarkers for various …
diseases. Circulating miRNAs were recently identified as biomarkers for various …
Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
J Winter, S Diederichs - RNA biology, 2011 - Taylor & Francis
Argonaute proteins are key players in microRNA (miRNA) processing and function. Next to
their role as RISC effector proteins mediating target silencing, they actively participate in …
their role as RISC effector proteins mediating target silencing, they actively participate in …
miR-511-3p modulates genetic programs of tumor-associated macrophages
Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated …
[HTML][HTML] Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia
S Mohr, C Doebele, F Comoglio, T Berg, J Beck… - Cancer cell, 2017 - cell.com
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …
overexpression but is currently considered undruggable. We therefore investigated whether …
A regulatory role for microRNA 33* in controlling lipid metabolism gene expression
L Goedeke, FM Vales-Lara… - … and cellular biology, 2013 - Taylor & Francis
hsa-miR-33a and hsa-miR-33b, intronic microRNAs (miRNAs) located within the sterol
regulatory element-binding protein 2 and 1 genes (Srebp-2 and-1), respectively, have …
regulatory element-binding protein 2 and 1 genes (Srebp-2 and-1), respectively, have …
Impact of serum storage conditions on microRNA stability
S Grasedieck, N Schöler, M Bommer, JH Niess… - Leukemia, 2012 - nature.com
As microRNAs (miRNAs) were found to be present in human serum in a remarkably stable
and cell-independent form, their potential as novel noninvasive biomarkers for physiological …
and cell-independent form, their potential as novel noninvasive biomarkers for physiological …
[HTML][HTML] Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells
PM Báez-Vega, IME Vargas, F Valiyeva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
MicroRNA-21 is overexpressed in most cancers and has been implicated in tumorigenesis.
Accumulating evidence supports a central role for the miR-21 guide strand (miR-21-5p) in …
Accumulating evidence supports a central role for the miR-21 guide strand (miR-21-5p) in …